Antibiotic, Bactericidal, Aminoglycoside Antibiotic, Ototoxic drug, Nephrotoxic drug
Brand Names
Amifuse E, Amiglyde-V®, Amiject D, Amikacin C Injection, Amikacin E, Amikacin K-9, Amikin®, Amimax™ C, Amimax™ E, Caniglide™, Equi-Phar EquiGlide™
Drug Information
Pharmacology
Aminoglycoside bactericidal antibiotic
Contraindications
General
- Contraindicated in patients with known sensitivity to this type of drug.
- Use with extreme caution with pre existing renal disease and with close monitoring and dose interval adjustment.
- Use with caution in neonates and geriatric patients, fever, sepsis and dehydration.
- Use with caution in patients with neuromuscular disease due to the neuromuscular blocking activity.
- Contraindicated in pregnancy.
General
- Do not use in animals intended for human consumption.
Horse
- Don’t breed mare for at least 8 hours after intrauterine infusion.
Dog
- Can cause irreversible ototoxicity – use with caution in working dogs, i.e. seeing eye dogs.
Cat
- Cats may be more sensitive to toxic effects.
Rabbit
- Contraindicated in rabbits as they adversely affect GI flora.
Adverse Effects
General
- Nephrotoxic, ototoxic auditory or vestibular.
- Can also cause neuromuscular blockade and respiratory paralysis, facial edema, pain and inflammation at injection site, peripheral neuropathy and hypersensitivity reactions.
- Rarely GI, hematologic and hepatic.
Interactions
Category Interactions
Anesthesia
- Neuromuscular blockade effects may be potentiated.
Cephalosporin antibiotic
- May cause additive nephrotoxicity-only documented with cephalothin.
Diuretic
- May increase toxicity.
Nephrotoxic drug
- May increase risk of nephrotoxicity.
Neuromuscular blocker
- May be potentiated.
Ototoxic drug
- May increase risk of ototoxicity.
Drug Interactions
Cephalothin sodium
- May cause additive nephrotoxicity.
Furosemide
- Nephrotoxicity is enhanced with furosemide.
Comments
Available Forms