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Amlodipine

Blood pressure treatment, Vasodilator, Calcium channel blocker, Antihypertensive, Negative Inotrope, Protein bound drug

Brand Names

Norvasc®

Drug Information

Pharmacology

Calcium channel blocker

Contraindications

General
  • Because of the slight negative inotropic effects, it should be used cautiously in patients with heart failure or cardiogenic shock.
  • Use cautiously in liver disease or those at risk for hypotension.
  • May be contraindicated in aortic stenosis.
  • Caution in pregnant or nursing animals.

Adverse Effects

General
  • Not well defined at this time, to now side effects have been minimal.
  • Anorexia and hypotension are possible.
  • Hypertension may rapidly recur if doses are missed.
  • Infrequently may cause azotemia, lethargy, hypokalemia, reflex tachycardia and weight loss.

Interactions

Category Interactions
Antihypertensive
  • May cause additive hypotension.
Beta adrenergic blocker
  • May cause hypotension.
Diuretic
  • May cause hypotension.
Protein bound drug
  • May displace other highly protein bound drugs resulting in increased activity of both.
Vasodilator
  • May cause hypotension.

Drug Interactions
Tadalafil
  • Potential to increase hypotensive effects.

Comments

Monitor blood pressure and ophthalmic exams.
Missed doses can result in rebound hypertension.
Can give with food.

Available Forms

Human
  • AmLODIPine tabs 2.5 mg, 5 mg, 10 mg.; Norvasc®
Veterinary – General
  • None

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