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Apoquel

Antiinflammatory, Immunosuppressive drug

Brand Names

Apoquel®

Drug Information

Pharmacology

Synthetic Janus Kinase (JAK) inhibitor. Oclacitinib inhibits the function of a variety of pruritogenic cytokines and pro-inflammatory cytokines, as well as cytokines involved in allergy that are dependent on JAK1 or JAK3 enzyme activity. It has little effect on cytokines involved in hematopoiesis that are dependent on JAK2.

Oclacitinib is not a corticosteroid or an antihistamine.

Contraindications

General
  • Apoquel® is not for use in dogs less than 12 months of age.
  • Apoquel® is not for use in dogs with serious infections.
  • Apoquel® may increase susceptibility to infection, including demodicosis, and exacerbate neoplastic conditions
  • Not for use in breeding dogs, or pregnant or lactating bitches.
  • The use of APOQUEL has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents.
  • Dogs receiving APOQUEL should be monitored for the development of infections, including demodicosis and neoplasia.

Adverse Effects

General
  • Adverse reactions reported included diarrhea, vomiting, anorexia, polydipsia, new cutaneous or subcutaneous lump, and lethargy. Decreased leukocytes (neutrophil, eosinophil, and monocyte counts) and serum globulin, and increased cholesterol and lipase are also possible.
  • Darkening areas of skin and fur is also possible.
  • Dogs receiving APOQUEL should be monitored for the development of infections, including demodicosis, and neoplasia.

Interactions

Category Interactions
Glucocorticoid
  • Safety has not been evaluated in combination with glucocorticoids.
Immunosuppressive drug
  • Safety has not been evaluated in combination with systemic immunosuppressants.

Drug Interactions
CycloSPORINE
  • Safety has not been evaluated in combination with cycloSPORINE.

Comments

Keep this and all drugs out of reach of children.
For use in dogs only.
Wash hands immediately after handling the tablets.
In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes and then seek medical attention.
In case of accidental ingestion, seek medical attention immediately.

Available Forms

Human
  • None
Veterinary – General
  • Tablets contain 3.6 mg, 5.4 mg, or 16 mg of oclacitinib as oclacitinib maleate per tablet. Each strength tablets are packaged in 20 and 100 count bottles. Each tablet is scored and marked with AQ and either an S, M, or L that correspond to the different tablet strengths on both sides; Apoquel®.

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