Atropine Ophthalmic

Anticholinergic, Mydriatic agent, Topical ophthalmic, Eye drop

Brand Names

Atrophate®

Blocks cholinergic receptors in the iris and ciliary body causing mydriasis and paralysis.

General

Do not use in cases of primary glaucoma. May precipitate acute congestive primary glaucoma in dogs predisposed to primary glaucoma.

General

May precipitate acute congestive primary glaucoma in dogs predisposed to primary glaucoma.
Repeated doses may cause systemic atropine toxicosis – mania and hyperthermia.
Salivation may occur secondary to the bitter taste.

Horse

Very frequent treatment may induce colic in horses secondary to systemic absorption and subsequent parasympathetic effects.

In dogs, maximal dilation occurs in 1 hour and lasts up to 120 hours.

Cats have a similar onset and effects may last up to 144 hours.

Horses have a particularly lasting effect.

Ointments will cause less hypersalivation than the solution form.

Human

Ointment – 5 mg/gm and 10 mg/gm in 3.5 gram tubes; Generic and a variety of trade names. Solution – 0.5%, 1% and 2% in unit dose droppers, 2, 5 and 15 mL bottles; Generic and a variety of trade names.

Veterinary – General

Ointment – 10 mg/gm 1% in 3.5 gram tubes; Atrophate ®. May not be currently available.