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Atropine Ophthalmic

Anticholinergic, Mydriatic agent, Topical ophthalmic, Eye drop

Brand Names

Atrophate®

Drug Information

Pharmacology

Blocks cholinergic receptors in the iris and ciliary body causing mydriasis and paralysis.

Contraindications

General
  • Do not use in cases of primary glaucoma. May precipitate acute congestive primary glaucoma in dogs predisposed to primary glaucoma.

Adverse Effects

General
  • May precipitate acute congestive primary glaucoma in dogs predisposed to primary glaucoma.
  • Repeated doses may cause systemic atropine toxicosis – mania and hyperthermia.
  • Salivation may occur secondary to the bitter taste.
Horse
  • Very frequent treatment may induce colic in horses secondary to systemic absorption and subsequent parasympathetic effects.

Comments

In dogs, maximal dilation occurs in 1 hour and lasts up to 120 hours.
Cats have a similar onset and effects may last up to 144 hours.
Horses have a particularly lasting effect.
Ointments will cause less hypersalivation than the solution form.

Available Forms

Human
  • Ointment – 5 mg/gm and 10 mg/gm in 3.5 gram tubes; Generic and a variety of trade names. Solution – 0.5%, 1% and 2% in unit dose droppers, 2, 5 and 15 mL bottles; Generic and a variety of trade names.
Veterinary – General
  • Ointment – 10 mg/gm 1% in 3.5 gram tubes; Atrophate ®. May not be currently available.

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