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Cidofovir

Antiviral, Topical ophthalmic, Eye drop, Topical antiviral

Brand Names

Cidofovir

Drug Information

Pharmacology

Antiviral – inhibits viral DNA replication

Contraindications

General
  • Systemic use is not recommended in cats.

Adverse Effects

General
  • Systemic administration may cause myelosuppression and nephrotoxicity.

Interactions

General Interactions
  • None identified with topical administration – additive myelosuppression and nephrotoxicity would be expected with systemic administration.

Comments

In vitro efficacy of commonly available antiviral agents for feline herpes virus is as follows: trifluridine > ganciclovir = idoxuridine = cidofovir = penciclovir = vidarabine > acyclovir > > foscarnet

Available Forms

Human
  • None – sterile solutions of cidofovir suitable for ophthalmic use may be prepared by diluting the commercially available injection to a final concentration of 5 mg/mL using 1% carboxymethylcellulose solution.
Veterinary – General
  • None

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