Diuretic, Glaucoma treatment, Carbonic Anhydrase Inhibitor, Potassium Depleting Diuretic
Brand Names
Daranide®
Drug Information
Pharmacology
Carbonic anhydrase inhibitor
Contraindications
General
- Contraindicated in patients with known sensitivity to this type of drug.
- Contraindicated in patients with liver or kidney failure, hypoadrenocorticism or those with electrolyte imbalance.
- Contraindicated in patients with severe pulmonary disease.
- Long term use is contraindicated in chronic angle closure glaucoma.
- Use with caution in patients with pre existing blood disorders and diabetics.
Adverse Effects
General
- Vomiting, diarrhea and loss of appetite are possible side effects of this medication. Give with food to minimize this effect.
- Sedation, excitement, depression, bone marrow suppression, crystalluria, dysuria, polyuria, electrolyte imbalance, liver insufficiency, rash and hypersensitivity reactions are also possible.
Interactions
General Interactions
- May cause false positive urine protein test results
- May decrease iodine uptake by the thyroid gland in hyperthyroid or euthyroid patients
Category Interactions
Corticosteroid
- Corticosteroids may exacerbate K+ secretion – especially significant in patients on digitalis.
Diuretic
- Diuretics may exacerbate K+ secretion – especially significant in patients on digitalis.
Drug Interactions
Amphotericin B
- Amphotericin B may exacerbate K+ secretion – especially significant in patients on digitalis.
Corticotropin (ACTH)
- Corticotropin may exacerbate K+ secretion – especially significant in patients on digitalis.
Insulin
- Rarely can interfere with hypoglycemic effects of insulin
Methenamine
- May negate the effects of methenamine compounds in the urine.
Methotrexate
- Can cause alkaline urine and affect excretion rate of methotrexate.
PHENobarbital
- Can cause alkaline urine and affect excretion rate of PHENobarbital.
Phenytoin sodium
- Phenytoin concurrently can cause osteomalacia
Primidone
- Primidone absorption can be inhibited.
- Primidone concurrently can cause osteomalacia
Procainamide
- Can cause alkaline urine and affect excretion rate of procainamide.
QuiNIDine
- Can cause alkaline urine and affect excretion rate of QuiNIDine.
Available Forms
Human
- May not be available- Tablets- 50 mg scored; Daranide®
Veterinary – General
- None
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