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Daranide (Dichlorphenamide)

Diuretic, Glaucoma treatment, Carbonic Anhydrase Inhibitor, Potassium Depleting Diuretic

Brand Names

Daranide®

Drug Information

Pharmacology

Carbonic anhydrase inhibitor

Contraindications

General
  • Contraindicated in patients with known sensitivity to this type of drug.
  • Contraindicated in patients with liver or kidney failure, hypoadrenocorticism or those with electrolyte imbalance.
  • Contraindicated in patients with severe pulmonary disease.
  • Long term use is contraindicated in chronic angle closure glaucoma.
  • Use with caution in patients with pre existing blood disorders and diabetics.

Adverse Effects

General
  • Vomiting, diarrhea and loss of appetite are possible side effects of this medication. Give with food to minimize this effect.
  • Sedation, excitement, depression, bone marrow suppression, crystalluria, dysuria, polyuria, electrolyte imbalance, liver insufficiency, rash and hypersensitivity reactions are also possible.

Interactions

General Interactions
  • May cause false positive urine protein test results
  • May decrease iodine uptake by the thyroid gland in hyperthyroid or euthyroid patients
Category Interactions
Corticosteroid
  • Corticosteroids may exacerbate K+ secretion – especially significant in patients on digitalis.
Diuretic
  • Diuretics may exacerbate K+ secretion – especially significant in patients on digitalis.
Drug Interactions
Amphotericin B
  • Amphotericin B may exacerbate K+ secretion – especially significant in patients on digitalis.
Corticotropin (ACTH)
  • Corticotropin may exacerbate K+ secretion – especially significant in patients on digitalis.
Insulin
  • Rarely can interfere with hypoglycemic effects of insulin
Methenamine
  • May negate the effects of methenamine compounds in the urine.
Methotrexate
  • Can cause alkaline urine and affect excretion rate of methotrexate.
PHENobarbital
  • Can cause alkaline urine and affect excretion rate of PHENobarbital.
Phenytoin sodium
  • Phenytoin concurrently can cause osteomalacia
Primidone
  • Primidone absorption can be inhibited.
  • Primidone concurrently can cause osteomalacia
Procainamide
  • Can cause alkaline urine and affect excretion rate of procainamide.
QuiNIDine
  • Can cause alkaline urine and affect excretion rate of QuiNIDine.

Comments

Availability has been as issue and may not be available.
Monitor intraocular pressure, serum electrolytes, CBC and for adverse effects.

Available Forms

Human
  • May not be available- Tablets- 50 mg scored; Daranide®
Veterinary – General
  • None