Analgesic, Seizure treatment, Anticonvulsant
Brand Names
Gabapentin, Neurotonin®
Drug Information
Pharmacology
Enhances release and action of GABA in the brain and inhibits neuronal sodium channels.
Contraindications
General
- Veterinary studies of the use of this drug are limited. Use with caution.
- Use with caution in patients with kidney disease and possibly with reduced dose.
Adverse Effects
General
- Veterinary studies of the use of this drug are limited.
- Sudden withdrawal should be avoided. Dose should be decreased gradually over 1 week if discontinuing use when treating seizures.
- Sedation, CNS depression – start with lower end dose and increase gradually may minimize these effects.
- Humans have reported dizziness, sleepiness and peripheral edema.
Interactions
Category Interactions
Antacid
- Bioavailability of gabapentin is decreased if given with antacids. Separate doses by 2 hours.
Drug Interactions
HYDROcodone
- Concomitant use may increase the efficacy of gabapentin and/or the risk for adverse effects of gabapentin. Also gabapentin may reduce the efficacy of HYDROcodone.
Morphine sulfate
- May increase gabapentin levels.
Available Forms
Human
- Capsules, 100, 300 and 400 mg; Neurotonin® Oral solution: 50 mg/mL in 470 mL bottles – CONTAINS XYLITOL – Use with cautionif at all in dogs and possibly cats; Neurotonin®.
Veterinary – General
- None
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