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Simplicef (Cefpodoxime)

Antibiotic, Bactericidal, Cephalosporin antibiotic, Third generation cephalosporin

Brand Names

Simplicef®

Drug Information

Pharmacology

Third generation cephalosporin – bactericidal antibiotic

Contraindications

General
  • Contraindicated in patients with history of hypersensitivity to cephalosporin antibiotics and possibly to penicillin related antibiotics because of the potential for cross reactivity.
  • Dosage may need to be adjusted in patients with kidney disease.
  • Use with caution in patients with seizure disorders.
  • Use with caution in breeding, lactating or pregnant animals as safety has not been established.
General
  • Extra label use of cephalosporin antibiotics in food animals is prohibited by the FDA.

Adverse Effects

General
  • Vomiting, diarrhea and loss of appetite are possible side effects.
  • Hypersensitivity reactions can occur-rash, fever, blood changes, anaphylaxis.

Interactions

Category Interactions
Antacid
  • May decrease absorption of cefpodoxime.
H-2 Antagonist
  • May decrease absorption of cefpodoxime.

Drug Interactions
Omeprazole
  • May decrease absorption of cefpodoxime.

Comments

Oral suspension is stable for 14 days after reconstitution when refrigerated.

Available Forms

Human
  • Oral tablets – 100 and 200 mg; Simplicef® and generic in bottles of 100 tablets and 250 tablets (Simplicef® only)
Veterinary – General
  • Tablet – 100 and 200 mg in btls of 100 tabs; Simplicef ®. Approved for use in dogs.

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