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Tylan

Antibiotic, Macrolide antibiotic, Hepatic enzyme inhibitor

Brand Names

Tylan®, TyloVed

Drug Information

Pharmacology

Macrolide antibiotic related to erythromycin, produced from Streptomyces.

Contraindications

General
  • Contraindicated in patients with known sensitivity to this type of drug.
Cattle
  • A withdrawal period has not been established in pre-ruminating calves. Do not use in calves to be processed for veal.
Horse
  • Most feel it is contraindicated in horses as severe and possibly fatal diarrheas may result.
  • Injection in horses has been fatal.
Swine
  • Do not attempt injection of the 50 mg product into pigs weighing less than 6.25 pounds (0.5 mL) unless the syringe is capable of accurately delivering 0.1 mL.
  • Do not attempt injection of the 200 mg product into pigs weighing less than 25 pounds (0.5 mL).
  • It is recommended that the 50 mg formulation be used in pigs weighing less than 25 pounds.

Adverse Effects

General
  • Pain and local reaction to injection, anorexia and diarrhea are possible side effects.
Ruminant
  • May cause severe diarrhea if oral form is used in ruminants.
Horse
  • Injection in horses has been fatal.
  • Any dose form may cause severe diarrhea.
Swine
  • In swine edema of rectal mucosa and mild anal protrusion with pruritus and erythema may also occur.
  • Adverse reactions, including shock and death may result from overdosage in baby pigs.

Interactions

General Interactions
  • Interactions may occur with carbamazepine.

Category Interactions
Hepatic enzyme inhibitor
  • Metabolism of other cytochrome P-450 metabolized drugs may be altered.
Lincosamide antibiotic
  • Lincosamides competitively compete for the same mechanism of action and therefore some feel should not be used concurrently.

Drug Interactions
Aminophylline
  • Decreased clearance of theophylline with possible increased risk for toxicity may occur.
Chloramphenicol
  • Chloramphenicol competitively compete for the same mechanism of action and therefore some feel should not be used concurrently.
Chloramphenicol
  • Tylosin may antagonize the activity of chloramphenicol.
CycloSPORINE
  • Interactions may occur with CycloSPORINE.
Florfenicol
  • May antagonize the bactericidal activity of tylosin. Clinical significance is not known.
Florfenicol / Flunixin meglumine
  • May antagonize the bactericidal activity of tylosin. Clinical significance is not known.
Tiamulin
  • Concurrent use of tylosin may reduce efficacy due to competition at site of action.

Comments

For information regarding compatibility in solution or combination with other drugs, refer to specialized reference material.

Available Forms

Human
  • None
Veterinary – General
  • Injection- 50 and 200 mg/mL; Tylan®, generic. Approved for non lactating dairy cattle, beef cattle, swine, dogs and cats. TyloVed Injection – Approved for cattle and swine. 100 gram bottles of 4000 mg/tsp; Tylan® Soluble. Approved for turkeys, chickens and swine. Not for layers. Many other products available as feed and water additive, often in combination with other products.

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